News-Medical.net
November 22, 2021
New research from Japan found several risk factors associated with greater waning immunity after vaccination. Old age and smoking were amongst those with some of the lowest antibody titers. Women more than men were also more likely to experience a rapid decline in antibody levels 3 to 6 months after receiving their second Pfizer-BioNTech dose.
Understanding who has at greater risk of waning immunity can help public health officials personalize vaccination regimens for individuals with the lowest antibody levels. This includes but is not limited to priority for booster shots, an individualized vaccination schedule, or using an adenovirus-based vaccine than an mRNA vaccine.
Recently, the United States authorized booster shots for any adult over the age of 18 who received their second vaccination at least six months ago.